MSH2 and glioblastoma: Glioblastoma cases characterized by the presence of mutations in DNA mismatch repair (MMR) genes, e.g., MSH2, MSH6, MLH1, and PMS2 have been suggested to be defined as having a hypermutated profile (Hunter et al., 2006; Cahill et al., 2007; Greenman et al., 2007; Tcga, 2008; Yip et al., 2009; Brennan et al., 2013; Daniel et al., 2019).