TNFRSF1A and glioblastoma: Finally, GBM cases belonging to the mesenchymal subtype are also characterized by the high expression of genes belonging to the TNF superfamily pathway and NF-kB pathway such as tumor necrosis factor receptor type 1-associated death domain (TRADD), RELB and TNF receptor superfamily member 1A (TNFRSF1A) (Tcga, 2008; Verhaak et al., 2010; Brennan et al., 2013; Wang et al., 2016).