In particular, stromal cells of the brain produce high levels of the classic immunosuppressive cytokines transforming growth factor β (TGFβ), interleukin-10 (IL-10) in response to inflammatory stimuli, including those derived from GBM tumors, in order to maintain homeostasis (Vitkovic et al., 2001; Gong et al., 2012). Here, IL10 is linked to glioblastoma.