The O-6-methylguanine-DNA methyltransferase (MGMT) locus has been found methylated in about 50% of GBM cases (Esteller et al., 2000; Paz et al., 2004; Hegi et al., 2005; Tcga, 2008; Zawlik et al., 2009; Malmstrom et al., 2012; Reifenberger et al., 2012; Armstrong et al., 2013; Brennan et al., 2013; Wiestler et al., 2013; Wick et al., 2014, 2018; Cominelli et al., 2015). Here, MGMT is linked to glioblastoma.