Glioblastoma cases belonging to the proneural subtype were found to be mainly characterized by alterations of PDGFRA and point mutations of IDH1. The focal amplification at the locus 4q12 harboring PDGFRA was associated with high levels of PDGFRA gene expression and the frequent presence of mutations in the PDGFRA gene. Here, PDGFRA is linked to glioblastoma.