MAPT and Alzheimer disease: However, the MCI and AD groups, both of which are associated with OI impairment and inclined to be associated with Aβ or tau burden (Jansen et al., 2015; Roalf et al., 2017; Villemagne et al., 2018; Jung et al., 2019), showed no correlation between the two at all among the different biomarker classifications.