Like the prion detected in olfactory epithelium of sporadic Creutzfeldt-Jakob disease (Tabaton et al., 2004), Aβ and tau also appeared in olfactory structures in AD and healthy subjects, including olfactory epithelium and OB (Kovacs et al., 1999; Wilson et al., 2007; Arnold et al., 2010; Brozzetti et al., 2020), both are susceptible to protein and enzyme modifications involved in AD pathogenesis (Dibattista et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.