Netrin-1 regulates axon guidance as both attractive and repulsive cues by binding to Unc5 family proteins, deleted in colorectal carcinoma (DCC), neogenin, down syndrome cell adhesion molecule (DSCAM), and integrin family proteins in vertebrates (Arakawa, 2004; Ly et al., 2008; Stanco et al., 2009; Adams and Eichmann, 2010; Castets and Mehlen, 2010; Dun and Parkinson, 2017). The gene discussed is DSCAM; the disease is carcinoma.