SNCA and Parkinson disease: As the phosphorylation of serine 129 of alpha synuclein (p-aSyn) is considered the dominant pathological modification in both familial and sporadic Lewy body diseases including PD, we have investigated the pathological relevance of the DMAs in this PD case using a phosphorylated alpha-synuclein antibody (p-aSyn, Ser129-P aSyn, 11A5, gift from Prothena) for fluorescent confocal microscopy, together with a Bielschowsky silver staining protocol (Uchihara, 2007) followed by multispectral imaging, on adjacent sections from same tissues as used for the X-ray/EM studies.