Interestingly, the protein level of RACK1 is decreased in 155 GC tissues compared with paired para-carcinoma tissues (Fig. 2A, B), and the level of RACK1 is negatively correlated with the depth of invasion, lymph node metastasis, clinical stage of 155 GC patients (Supplementary Table S1 and Fig. 2C). Here, RACK1 is linked to metastatic malignant neoplasm in the lymph nodes.