Interestingly, we found that M435-1279 has low cytotoxicity to normal cells of gastric mucosa at effective inhibition concentration for GC cells, suggesting that M435-1279 could suppress GC progression through UBE2T-medicated Wnt/β-catenin hyperactivation without impairing its physiological function in the meantime. This evidence concerns the gene UBE2T and gastric cancer.