When using pharmacological inhibitors of G9a and LSD1 on CRC cells, we observed lower EC50 values for BIX-01294 and UNC0642 (G9a inh.: 1.65μM and 2.58μM respectively) compared to LSD1 inhibition (GSK-LSD1: 22.1μM) (Fig. 1G). Here, EHMT2 is linked to colorectal carcinoma.