Moreover, multiple genes involved in negative regulation of canonical Wnt signaling (GO:0030178), repression of epithelium-to-mesenchyme transition (Onder E-cadherin targets up) [34], and extracellular matrix organization (GO:0031012) were silenced in CRC (vs. normal) and co-enriched with G9a and H3K9me2 in patient-derived CCSCs (Fig. 4H, Table-S7 and S8). The gene discussed is EHMT2; the disease is colorectal carcinoma.