SNCA and synucleinopathy: We next evaluated the protective potential of TfR2 deletion in two synucleinopathy models, namely in (1) mice in which human alpha-synuclein overexpression was induced by a stereotaxic injection of recombinant adeno-associated (rAAV) viral vectors in the substantia nigra [33], and (2) mice in which alpha-synuclein PFF were stereotaxically injected in the striatum [34].