Further, Kaplan–Meier analysis showed that ZMYND8 independently or in the presence of low dose of doxorubicin, induced gene expression profiles that are associated with better DMFS (Fig. 4d and Supplementary Fig. 6c), and these genes are preferentially expressed in normal-like or low grades of breast tumors (Fig. 4d and Supplementary Fig. 6d). This evidence concerns the gene ZMYND8 and breast neoplasm.