Further, GSEA (Gene Set Enrichment Analysis) analyses of ZMYND8-positively-regulated genes suggest that ZMYND8 alone or in combination with doxorubicin positively regulates gene transcription and cancer pathways (Fig. 4c and Supplementary Fig. 5c), whereas doxorubicin alone affected cell-cycle-related pathways (Fig. 4c) indicating its role in replication stress and DNA damage. Here, ZMYND8 is linked to cancer.