Similarly, we found upregulation in the expression of pluripotency (POUSF1, NANOG, SOX2, BMI1, SOX9, and NOTCH1), drug resistance (ABCB1, ABCC1, and ABCC2), EMT (SNAI2, TWIST1, ZEB1, and VIM), and stemness (CD44 and CD24)-related genes upon knockdown of ZMYND8 by smart-pool siRNA in invasive breast cancer cells MDA-MB-231 and MDA-MB-468 (Fig. 1e–i and Supplementary Fig. 1). Here, TWIST1 is linked to invasive breast carcinoma.