CD4 and neoplasm: As shown in Figure 4, FGL2 expression correlated negatively with ESCA tumor purity and positively with the infiltrating levels of B cells (r = 0.331, P = 5.85e-06), CD8+ T cells (r = 0.147, P = 4.93e-02), CD4+ T cells (r = 0.323, P = 1.07e-05), macrophages (r = 0.559, P = 3.37e-16), neutrophils (r = 0.337, P = 3.66e-06) and DCs (r = 0.268, P = 2.73e-04).