To better understand whether FGL2 is a crucial determinant of the TME and tumor metastasis in esophageal cancer, we compared the cytokine levels among EC109/9706 (ESCC) cells cultured alone, co-cultured with M0 macrophages or co-cultured with M2 macrophages (Figure 7A). The gene discussed is FGL2; the disease is esophageal squamous cell carcinoma.