Specifically, higher FGL2 expression was marginally associated with a poorer prognosis in ESCC patients (OS hazard ratio [HR] = 2.57, 95% confidence interval [CI] = 1.05 to 6.28, P = 0.033; RFS HR = 3.78, 95% CI = 1.43 to 9.98, P = 0.0039) (Figure 3A, 3B). Here, FGL2 is linked to esophageal squamous cell carcinoma.