Transcription factors (TFs), including zinc-finger-binding transcription factors Snai1 and Slug (also named as Snai2), the basic helix-loop-helix (bHLH) factors Twist1 and Twist2, and the zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2, have been identified to mediate the EMT and also contribute to tumor formation, invasiveness, and metastasis in osteosarcoma [32, 33]. The gene discussed is SNAI2; the disease is osteosarcoma.