EPB41L3 and osteosarcoma: To evaluate the expression of EPB41L3 in osteosarcoma, we analyzed microarray data of the Gene Expression Omnibus (GEO) dataset (Access id: GSE42352) and found that EPB41L3 was significantly increased in osteosarcoma tissues (versus normal mesenchymal stem cells (MSCs), fold change=5.8245, p=0.0001; versus osteoblast cells (OBs), fold change=5.6668, p=0.0002) (Figure 1A).