EPB41L3 and osteosarcoma: To further examine the biological functions of EPB41L3 in human osteosarcoma, the expression of EPB41L3 was knocked down using two EPB41L3-specific siRNAs (siEPB41L3#1 or siEPB41L3#2) in U2OS and MG63 cells respectively, and knockdown efficiency was confirmed by qRT-PCR at 72 h post-transfection.