Neuropeptides, including corticotropin releasing factor (CRF), dynorphin, enkephalin, tachykin 2, and neurotensin are highly enriched in the CeA (Kim et al., 2017; McCullough et al., 2018), where they have been shown to modulate multiple aspects of conditioned threat and anxiety-related behaviors (Regev et al., 2012; Andero et al., 2014; Fadok et al., 2017; Sanford et al., 2017; Ahrens et al., 2018; Dedic et al., 2018b; Jo et al., 2020). This evidence concerns the gene PDYN and Anxiety.