PDYN and Anxiety: CRF and dynorphin are broadly linked to stress, fear, and anxiety (Land et al., 2008; Bruchas et al., 2009; Chavkin, 2013; Fadok et al., 2017; Sanford et al., 2017; Ahrens et al., 2018; Dedic et al., 2018a; Jo et al., 2020).