In humans, ROR2 mutations are associated with diseases such as dominant Brachydactyly B (BDB, a shortening of the digits) (Oldridge et al., 2000) and recessive Robinow syndrome (RRS), which is associated with short-limbed dwarfism, abnormal vertebrae, fusion of the ribs and abnormal facial structures (Afzal and Jeffery, 2003). The gene discussed is ROR2; the disease is autosomal recessive Robinow syndrome.