NOTCH1 and oropharynx cancer: While overexpressed NOTCH1 protein levels correlated with improved OS (p < 0.001) in patients with oropharyngeal cancer [94], it was an independent prognostic factor for poor OS (p = 0.015) and correlated with distant metastases (p = 0.003) and tumor differentiation (p = 0.031) in patients with hypopharyngeal squamous cell carcinoma [58].