Additional genetic evidence supporting a role for NOTCH1 in carcinogenesis of HPV-driven squamous carcinomas was reported by Zhong et al. [44] who used an elegant model of transposon-mediated insertional mutagenesis (i.e., “Sleeping Beauty”) in mice with conditional co-expression of HPV E6/E7 in basal epithelium. Here, NOTCH1 is linked to squamous cell carcinoma.