TNF and Meniere disease: Frejo et al. were demonstrated that locus PSORC1 and the allelic variant rs4947296, both located 6p21.33 mediate inflammation of the blood-labyrinth barrier and endolymphatic sac by regulation of gene expression and upregulation of NF-κB translation in the TNF-like weak inducer of apoptosis/Fn14 pathway in bilateral Meniere’s disease [31].