DLK1 and Anxiety: In contrast, DLK1Null mice spent more time in the open arms of the EPM compared to Controls, suggesting that loss of LHA DLK1 might reduce anxiety behavior (Figure 7A, Control Closed Arm = 9.8 ± 2.5% vs. DLK1Null Closed Arm= 52.6 ± 5.5%; Control Open Arm = 67.2 ± 5.1% vs. DLK1Null Open Arm = 30.3 ± 6.8%, p < 0.05).