For example, APOBEC3B interferes with the tri-methylation at the 27th lysine residue of the histone H3 protein (H3K27me3) epigenetic modification of chromatins, leading to aberrant chemokine expression and subsequent formation of a microenvironment suitable for cancer progression, which seems to be functioning in a deaminase-independent manner [182]. Here, APOBEC3B is linked to cancer.