NFKB1 and obesity due to melanocortin 4 receptor deficiency: However, during obesity, multiple means such as FFAs, microbiota-derived lipopolysaccharide (LPS), inflammatory cytokines, advanced glycation end products (AGEs), endoplasmic reticulum (ER) stress, and oxidative stress, can recruit inflammatory signalling cascades that can interfere with different NF-kB molecules.