In particular, ROS liberate TXNIP (thioredoxin-interacting protein), a crucial protein associated with insulin resistance, which stimulates the assembly of a cytosolic multiprotein complex, namely NLRP3 (nucleotide oligomerisation domain (NOD), leucine-rich repeat (LRR), and pyrin domain (PYD)) inflammasome, that promotes inflammation. This evidence concerns the gene TXNIP and Insulin resistance.