Various constipation phenotypes, including stool parameters, histopathological structure, and mucin secretion, as well as their molecular mechanisms, such as mAChR signaling and endoplasmic reticulum (ER) stress response, were detected in Tg2576 Tg mice showing Alzheimer’s Disease (AD)-like phenotypes [7]. The gene discussed is MUC5AC; the disease is Alzheimer disease.