In addition to the above-mentioned pro-inflammatory markers, it has been shown that the levels of an acute inflammatory phase protein, the C-reactive protein (CRP), were found increased in schizophrenic patients [63] correlating with negative symptom severity [64], underlining that the elevated blood CRP levels could be considered as a useful peripheral biomarker of schizophrenia [65]. This evidence concerns the gene CRP and schizophrenia.