The influence of miRNA expression on mRNA–lncRNA crosstalk has been studied in esophageal squamous cell carcinoma (ESCC), comparing two intrinsic subtypes and identifying the “loss” of miR-186-mediated PVT1–mRNA and miR-26b-mediated LINC00240–mRNA crosstalk [151] as driver events of ESCC development. The gene discussed is LINC00240; the disease is esophageal squamous cell carcinoma.