CFTR and pancreatitis: In our previous Italian study on patients heterozygous for D1152H and carrying a class I-III or IV–V variant in trans (N = 84), only 1 patient (4%) in the group of 25 patients < 10 y carrying a severe class I-III CFTR variant (i.e., who would belong to group A in the current study) developed chronic or recurrent pancreatitis [15].