The study demonstrates that CRMS/CFSPID subjects with D1152H in trans with a CFTR variant classified as CF-causing according to the CFTR2 database (Group A) more frequently develop episodes of pancreatitis, isolation of P. aeruginosa and respiratory exacerbations in the first year of life, or they required respiratory physiotherapy, radiological examinations, or saline supplementation. The gene discussed is CFTR; the disease is cystic fibrosis.