SLC11A2 and nutritional disorder: Olfactory DMT1 also appeared to play a critical role in Mn uptake into the brain, as the nasal absorption of Mn is significantly reduced in DMT1-mutated b/b rats [45] and an iron deficiency increased the olfactory DMT1 levels, suggesting the importance of olfactory DMT1 in Mn transport to the brain and its modulation by the iron status [45].