Several factors may be involved in age-related nuclear cataracts: connexins and aquaporins (AQPs) related to metabolite transport in the lens, transient receptor potential cation channel subfamily V member 1 (TRPV1) and transient receptor potential cation channel subfamily V member 4 (TRPV4) proteins involved in lens ion transport [65], the post-translational modification of various crystallin proteins in the deep lens cortex and nucleus [66,67], and the oxidation of the lens nucleus due to antioxidants’ inability to reach the lens nucleus [68]. The gene discussed is TRPV1; the disease is Age-related nuclear cataract.