CXCL8 promotes CML cell proliferation [21] and previous reports suggest that CXCL8 expression is modulated both by BCR-ABL1 expression (causing an increase) and TKI treatment (causing inhibition of CXCL8) [22]. The gene discussed is CXCL8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.