XDH and diabetes mellitus: Outcomes from two recent high profile trials; the Preventing Early Renal Loss in Diabetes (PERL) trial and the Controlled Trial of Slowing of Kidney Disease Progression from the Inhibition of Xanthine Oxidase (CKD-FIX) over 3 and 2 years, respectively, did not show benefit in T1DM patients with mild to moderate kidney disease [107,108].