In addition, human biopsies, as well as experimental models of FSGS, have uncovered a causative role for the endothelin-1/endothelin receptor type A (Ednra) axis in promoting endothelial cell dysfunction and loss of the glomerular endothelial glycocalyx by increased degradation of glucosaminoglycans [47,48,49]. The gene discussed is EDNRA; the disease is focal segmental glomerulosclerosis.