Experimental models of T1DM and T2DM with eNOS knockout (eNOS−/−) have been shown to recapitulate glomerular lesions seen in human DKD, such as mesangial expansion, podocyte injury and depletion, albuminuria and focal segmental glomerular sclerosis (FSGS) [37,38]. Here, NOS3 is linked to diabetic kidney disease.