Experimental models of T1DM and T2DM with eNOS knockout (eNOS−/−) have been shown to recapitulate glomerular lesions seen in human DKD, such as mesangial expansion, podocyte injury and depletion, albuminuria and focal segmental glomerular sclerosis (FSGS) [37,38]. The gene discussed is NOS3; the disease is type 1 diabetes mellitus.