Specifically, platinum compounds seem to trigger immunogenic cell death (ICD), characterized by a series of molecular changes, such as increased cell surface expression by dying tumor cells of calreticulin (CRT, release of ATP and HMGB1 (high-mobility group box 1), production of IFN-α (interferon alpha) and secretion of CXCL10 (CXC-chemokine ligand 10) [21]. The gene discussed is HMGB1; the disease is neoplasm.