TNFRSF11A and osteoporosis: Expression of miR-503, targeting RANK, is strongly reduced in circulating CD14+ macrophages of human osteoporosis patients in comparison to normal patients, and it silences miR-503 with an antagomir that promotes RANK expression and osteoclast differentiation, promotes bone resorption, and decreases bone mass in an ovariectomized mouse model [92].