In line with these findings, PTPN13 overexpression in Capan-1 pancreatic carcinoma cells negatively regulate FAS-mediated apoptosis [54], and PTPN13 silencing by siRNA in SW480 colorectal cancer cells increases FAS/FasL-mediated apoptosis [55]. The gene discussed is PTPN13; the disease is exocrine pancreatic carcinoma.