Its methylation is consistently associated with decreased PTPN13 expression [103], and has been observed in many hematologic (94% of 16 non-Hodgkin lymphoma cell lines, 50% of 6 Hodgkin lymphoma cell lines) and solid cancer cell lines (67% of 12 HCC cell lines, 60% of 10 gastric cancer cell lines, and 30% of 10 breast cancer cell lines). The gene discussed is PTPN13; the disease is hepatocellular carcinoma.