For instance, in HCT116 colon cancer cells, PTPN13 inactivates SRC through interaction with reversion-induced LIM domain protein (RIL) [68], and in A549 pulmonary and Caco-2 colon adenocarcinoma cells, it inhibits the ERBB3/ERBB2 receptors through association with nectin-like molecule 2 (NECL2) [18]. This evidence concerns the gene PTPN13 and colonic neoplasm.