PTPN13 and hepatocellular carcinoma: In addition, the nonsense Tyr1758*** (T > A) and missense Glu745Gln mutations have been found in hepatitis B virus-induced HCC samples, and the L1424P false-sense mutation, which is located in a protein-interacting PDZ domain (genomic position 87687597), may affect PTPN13 function.