Interestingly, our analysis underlined the role of type III IFN (IFNL1, INFL2, and INFL3) and several cytokine-coding genes such as CXCL2/CXCL8 (Figure 3A,B) that are upregulated following simple SARS-CoV-2 infection and even more upregulated in the context of superinfection, arguably illustrating an enhanced specific response to control infection in both models. The gene discussed is IFNL1; the disease is infection.