APC and Familial adenomatous polyposis: In particular, in a meta-analysis on risk factors predicting desmoid occurrence in patients with FAP, Sinha et al. found that in a total of 4625 FAP patients—559 (12%) of whom developed DTs—a positive family history was the most significant risk factor (odds ratio (OR) 7.02, 95% CI: 4.15–11.9, p < 0.001), followed by APC gene mutation 3′ to codon 1399 (OR: 4.37, 95% CI: 2.14–8.91, p < 0.001) and previous abdominal surgery (OR: 3.35, 95% CI: 1.33–8.41, p = 0.01) [17].