Whereas systemic DLBCL with co-expression of c-Myc and Bcl-2 (double-expressor) and/or co-rearrangement of MYC and BCL2 and/or BCL6 (double or triple hit lymphoma) has been associated with a worse prognosis, the findings were inconclusive for PCNS DLBCL. Here, BCL6 is linked to diffuse large B-cell lymphoma.