Using whole-exome sequencing of 41 PCNS DLBCL cases, Fukumura et al. identified other frequently mutated genes in the NF-ĸB signaling pathway, including PIM1, BTG2, CD44, XBP1, CD79B, and NFKB1E [42]. The gene discussed is PIM1; the disease is diffuse large B-cell lymphoma.