The cytokines IFN-γ, IL-2, IL-7, IL-12, IL-15, IL-18, IL-21, and IL-27, promoted neuroblastoma regression via enhancing the efficacy of effector cells, whereas VEGF, IL-6, and IL-10 induced neuroblastoma progression through their immunosuppressive activities. The gene discussed is IL2; the disease is neuroblastoma.