CXCR1-expressed NKG2D-targeted CAR NK cells had enhanced tumor trafficking with preserved antitumor effects in ovarian cancer xenograft models [104], while anti-CD147 CAR NK exhibited potent cytotoxicity against hepatocellular carcinoma (HCC) cell lines in vitro and patient-derived HCC xenograft mouse models [100]. The gene discussed is KLRK1; the disease is neoplasm.