Using transgenic mice with cardiac-specific overexpression of PPARα, wildtype, and PPARα knockout mice, the authors demonstrated using ischemia (18 min) and reperfusion (40 min) that PPARα knockout mice had significantly lower FAO, higher glucose oxidation rates, and better recovery of cardiac power (calculated as the product of developed pressure and cardiac output) than animals from the two other groups. This evidence concerns the gene PPARA and ischemia.