On a similar theme, Venkatesh et al. [67] in one of his extensive murine studies explored the influence of neurons on glioma growth and demonstrated that certain cells, pyramidal neurons, promote proliferation via the PI3K/mTOR pathway in adult and paediatric high grade glioma (HGG) cell cultures by secreting neuroligin-3 (NLGN3) [67] and targeting NLGN3 could prove a basis for a promising therapy in HGG [68]. This evidence concerns the gene NLGN3 and central nervous system cancer.