Zagzag D et al. in an elegant study [46] described how, under the stimulus of hypoxia and Vascular Endothelial Growth Factor (VEGF), stromal cell-derived factor 1 alpha (SDF-1α), also known as C-X-C motif chemokine 12 (CXCL12), expressed by neurons, blood vessels, subpial regions, and white matter interacts with its own receptor expressed by glioma cells, inducing tumour cell migration in a chemokine receptor type 4 (CXCR4) and 7 (CXCR7) anchorage-dependent manner [47]. Here, CXCL12 is linked to central nervous system cancer.