The authors claim to provide the first evidence of single cell LCM RNA-seq of different regional compartments within “de novo” IDH1-wt GB samples, particularly glial cells cuffing neurons and the neurons themselves reporting how satellite cells show an up-regulation of genes related to integrins, specific metalloproteinases, aquaporins and cell division control protein 42 homolog (CDC42) signalling, which are known to be involved in invasion and glioma aggressiveness [42,43]. This evidence concerns the gene CDC42 and glioma.