In the blood of patients with RA, elevated levels of fibrinogen [21,22,23], tissue-type plasminogen activator [24,25], tissue factor [26], plasminogen activator inhibitor-1 [25,27], and D-dimer [22,26,28] were found, which together indicate hypercoagulability and a pre-thrombotic condition [6,29]. Here, F3 is linked to rheumatoid arthritis.