CSF2 and neoplasm: Additionally, NK cells rapidly produce chemokines and cytokines upon activation, including interferon (IFN)-γ, granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-10, CCL3, CCL4, CCL5, and CXCL8 that recruit and affect the function of hematopoietic and nonhematopoietic cells in the tumor microenvironment (TME) [21].