Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) cytogenetically characterized by a balanced reciprocal translocation between chromosomes 15 and 17, which results in the fusion between the promyelocytic leukemia (<i>PML</i>) gene and retinoic acid receptor-α (<i>RARα</i>) [...]. This evidence concerns the gene PML and acute promyelocytic leukemia.