Valproic acid, an effective antiepileptic drug, exerts a potential anti-GBM effect via the inhibition of angiogenesis and the downregulation of 0-6-methylguanine-DNA methyltransferase (MGMT) expression, which has been found to decrease CD44 expression in several glioma cell lines [38]. The gene discussed is MGMT; the disease is central nervous system cancer.