Class I PI3Kα has an essential role in physiological cardiac hypertrophy and contractility, and is activated in cardiomyocytes by insulin or insulin-like growth factor-1 (IGF-1), while in endothelial cells, fibroblasts and vascular smooth muscle cells by fibroblast growth factor (FGF), platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF). The gene discussed is VEGFA; the disease is hypertrophy.