The aberrant P-Tau levels were explained by deregulation of two genes localized on Hsa21: (i) the dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene and (ii) the regulator of calcineurin 1 (RCAN1) gene, both expressed in DS brains and implicated in the dysregulation of Tau phosphorylation [89]. Here, RCAN1 is linked to Dravet syndrome.