AKT1 and glioma: Control experiments utilizing PI3K inhibitors confirmed that the activation of apoptosis is inhibited by PI3K/Akt/mTOR caused similar results in fucoxanthin-treated cells, that is, fucoxanthin can inhibit glioma cells by inhibiting the PI3K/Akt/mTOR pathway, realizing mTOR and PI3K dual inhibition, in principle, it not only inhibits the activity of mTOR, but also directly inhibits the activity of AKT, so it circumvents the feedback loop of S6K1-IRS1.