The combination of fucoidan (Fc) and fucoxanthin (Fx) inhibits the activity of xanthine oxidase (XO) in the liver and regulates the expression of proteins (GLUT9 and URAT1) related to the uric acid (UA) transporter in the kidney, reducing the serum level of UA and preventing hyperuricemia [101]. The gene discussed is XDH; the disease is hyperuricemia.