GAPDH and paracoccidioidomycosis: Interestingly, glyceraldehyde-3-phosphate dehydrogenase and fructose-bisphosphate aldolase are expressed in high levels among highly virulent P. brasiliensis complex isolates found to trigger disseminated disease in a murine model of PCM [54,106] and have been observed in Paracoccidioides extracellular vesicle preparations of the Pb18 isolate [90].