Shen et al. explored the concept of glutaminase dependency in the context of ovarian cancer, in which >45% of patients’ tumors overexpress MYC. Elevated MYC expression correlated with glutaminase in immortalized cell lines and primary cultures, and overexpression of MYC and GLS were associated with chemoresistance and worse disease outcome [214]. The gene discussed is GLS; the disease is ovarian carcinoma.