Aurora Kinases: Given the similarities and genetic overlap between Aurora kinases A and B, many aurora kinase inhibitors are nonselective, other than Alisertib (MLN8237), which is specific to Aurora A and Barasertib (AZD1152), which is specific to Aurora B. VX-680 and AZD1152 have been studied specifically in MYC-overexpressing cancers preclinically. The gene discussed is MYC; the disease is cancer.