Using RNAseq and quantitative polymerase chain reaction (qPCR), Jung et al. identified upregulated expression of MCOLN1, which encodes TRPML1, in cancer cells harboring activating (oncogenic) HRAS mutations and found that HRAS knockdown in HRAS-driven HN31 cells decreased MCOLN1 expression [12]. Here, MCOLN1 is linked to cancer.