Nonetheless, it is important to appreciate the context-dependent and double-edged sword effect of TRPML1 to modulate autophagy, considering that TRPML1 senses ROS production and stimulates adaptive responses to eliminate ROS and maintain survival in some conditions, while in others, such as glioblastoma, TRPML1 activation is tumor suppressive and is associated with autophagic cancer cell death. The gene discussed is MCOLN1; the disease is neoplasm.