When investigating the cooperating effect of expressing mutated kinases (such as mutant FLT3, RAS or KIT) together with by retrovirally transducing murine bone marrow cells with RUNX1/ETO into lethally irradiated syngeneic mice, all animals developed AML [30,31,32,33,34]. The gene discussed is RUNX1; the disease is acute myeloid leukemia.