Indeed, genomic profiling of adult and pediatric cases with CBF leukemia by whole genome and whole exome sequencing revealed that in t(8;21) cases, by average 11.86 ± 6.40 and 12.56 ± 6.55 mutations with functional consequences in t(8;21) were detectable in adults and pediatric patients, respectively. This evidence concerns the gene CEBPZ and leukemia.