These efforts have led to the development of highly effective specific inhibitors in other types of leukemia by targeting the oncoproteins causing APL (PML/RAR; ATRA) and CML (BCR/ABL; imatinib), but have failed to effectively target others in AML, such as the FLT3-ITD growth factor receptor whose mutation causes a particularly aggressive type of AML. The gene discussed is ABL1; the disease is leukemia.