Although we were not able to check whether the stronger association of coarse grains with blood pressure in men was driven by dietary fiber or potassium, the renin–angiotensin–aldosterone system, a major physiological system for blood pressure control, was highly influenced by sex hormones and menopause status in women [30], and was shown to be downregulated in hypertensive mice fed with a high-fiber diet in favor of preventing the onset of hypertension [31]. This evidence concerns the gene REN and hypertensive disorder.