Indeed, a meta-analysis evaluated 4.3–9.5% of COVID-19 patients with a bacterial infection, which was more common in severe patients (8.1%) [47] and so were the incidences of co-infection from other microbes, including fungi and other viruses, in critically ill COVID-19 patients who suffer dysfunctional IFN and other immune reactions [48]. The gene discussed is IFNA1; the disease is COVID-19.