IFNA1 and congenital rubella syndrome: In addition to induction of IFNs/ISGs, the canonical and especially non-canonical IFN signaling pathway also lead to the production of inflammatory cytokines, which is further exacerbated by the virus suppression of ACE2 activity to develop into a cytokine release syndrome (CRS) or cytokine storm [30,31,34,35,36,37,38].