The non-canonical IFN signaling for that responding to pDNA through cGAS-STING and non-canonical ISG stimulation via IFN-TNF epigenetic coordination might occur at the later stage, accompanying massive cell death from pyroptosis (a highly inflammatory form of programmed cell death in infected cells) and NETosis (an immunologically regulated form of neutrophil cell death), as seen in severe COVID-19 cases [16,17,18,33,34,35,36,37,38]. This evidence concerns the gene STING1 and COVID-19.