Liang et al. generated encapsulating-CCL18 siRNA nanoparticles, composed from poly(ethylene glycol)-b-poly (ε-caprolactone) (PEG-b-PCL), poly(ε-caprolactone)-b-poly (2-aminoethyl ethylene phosphate) (PCL-b-PPEEA), and PCL homopolymer, with the aim to target breast cancer TAMs. This evidence concerns the gene CCL18 and breast carcinoma.