RAC2 and breast carcinoma: An exemplary study carried out by Fokkelman and colleagues [91] identified myosin phosphatase target 2 (PPP1R12B), Homeodomain Interacting Protein Kinase 3 (HIPK3), and Ras-related C3 botulinum toxin substrate 2 (RAC2) as the main modulators of cellular traction forces and cell migration mechanisms in breast cancer.