ETS1 and malignant glioma: Notably, two genes involved in cancer map in Rattus norvegicus 8q: IL8 and ETS1. IL-8 induces an increase in the expression of Matrix Metalloprotease (MMP) 13, a zinc-binding proteolytic enzyme that facilitates cell migration and progression of malignant glioma, also by increasing the blood brain barrier permeability [65].