HRAS and neoplasm: Prostate cancer cell-derived EVs have been shown to carry tumorigenic molecules (e.g., ras transcripts (H-ras and K-ras), Rab proteins (Rab1a, Rab1b, and Rab11a), and oncogenic miRNAs (miR-125b, miR-130b, and miR-155) that block tumor suppressors such as Lats2 and PDCD4 to allow transformation of adipose-derived stem cells in primary as well as metastatic sites in cancer patients, eventually promoting tumor clonal expansion [121].